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- This position is open until filled.
The Cryo-TEM Facility at UCSD is a state-of-the-art, cross-campus facility dedicated to the high-resolution imaging of molecular and cellular samples under cryogenic conditions. The facility currently houses four TEMs: (1) A Tecnai Sphera, a 200keV instrument with a LaB6 gun and equipped with a CCD camera; (2) A Tecnai Polara, a 300keV instrument with a Field Emission Gun (FEG) and a DE20 direct electron detector; (3) An FEI Talos Arctica, a 200keV instrument with a FEG, Volta phase plates and a K2 Summit direct electron detector; (4) A Titan Krios, a 300keV instrument with a FEG, Volta phase plates, a Quantum energy filter and a K2 Summit. Another Titan Krios, equipped with Volta phase plates and a K3 direct electron detector will be delivered in June 2019.
The facility also houses an Aquilos cryo-DualBeam for Life Sciences for the preparation of cryo-electron tomography samples using Focused Ion Beam milling, as well as all the ancillary equipment required for cryo-TEM.
The Facility already has a Cryo-EM Project Specialist who assists users in the preparation and imaging of biological cryo-TEM specimens. Responsible for the operational management of a multi-million dollar cryo-transmission electron microscopy (cryo-TEM) facility and enabling outside users to benefit from its capabilities. Responsibilities include: managing the day-to-day operations of the facility, training, and supervising scientists in all aspects of the use of microscopy equipment, sample preparation, data acquisition and processing.
Critical to the position will be the ongoing development and implementation of cutting edge techniques for sample preparation and imaging under cryo-TEM conditions; interfacing with potential users across the UCSD campus to help them develop and implement workflows that can lead to high-resolution structure determination; and ensuring that the software-driven automation of the microscopes incorporates the latest developments in the field. Applies extensive knowledge as a research professional with an in-depth understanding of statistical and/or other analysis techniques designed to support research projects of broad scope and complexity. May function as a team lead.
Must have the ability to manage a large, multi-user research facility and to perform all duties with limited supervision.
Must be able to quantitatively analyze scientific results, communicate effectively with faculty, students, staff, vendors, and service engineers, have an acute attention to detail, keep accurate and clear records, spearhead the planning and writing of instrument-related grant proposals as needed, keep abreast of scientific literature concerning relevant new instrumentation and specimen preparation and imaging techniques, and manage time, set priorities and meet deadlines.
Previous teaching experience or experience training large numbers of students and staff in the operation of transmission electron microscopes (especially those equipped with field emission guns).
Advanced ability to think creatively to recommend action steps or strategize solutions relative to research.
In-depth knowledge of research function. Advanced skills in analysis and consultation. Advanced research skills at a level to evaluate alternate solutions and develop recommendations.
Advanced skills associated with statistical analysis, database management and systems programming.
Advanced ability to communicate complex information in a clear and concise manner both verbally and in writing.
Advanced project management skills. Ability to lead and influence within and external to project team.
Superior organizational and interpersonal skills.
Excellent manual dexterity and visual acuity are required.
Job offer is contingent upon a satisfactory clearance based on background check results.
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