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#105723 Mouse Model Specialist

Filing Deadline: Tue 9/29/2020

UCSD Layoff from Career Appointment: Apply by 09/18/20 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 09/29/20. Eligible Special Selection clients should contact their Disability Counselor for assistance.


The UCSD Department of Obstetrics, Gynecology, and Reproductive Sciences strives to provide excellent clinical care to women while conducting cutting-edge basic, translational, and clinical research in reproductive health.

Under supervision, the Staff Research Associate will participate in an integrated research team focused on cutting edge research related to roles of the vaginal microbiome and carbohydrate biology in women’s health. The Staff Research Associate will independently to carry out preclinical studies employing mouse infection/inoculation models. The successful candidate will be trained in mouse models of vaginal and urinary exposures and will carry out research to understand the roles of the vaginal microbiota and specific vaginal bacteria in human health and disease.

This incumbent will assist with other lab duties such as ordering and receiving, maintaining lab protocols for biological and chemical safety and animals, routine equipment maintenance. Work with mouse handling and basic routes of administration. Manage colony timed mating, genotyping, establishment/phenotyping of transgenic lines, histology. Work with microbiology/microbiome, molecular biology (bacterial genetics, qRT-PCR, plasmid construction etc.), biochemistry (chromatography, enzyme assays, etc.), or flow cytometry.


  • Theoretical knowledge of general biology, biochemistry, cell biology, and molecular biology, or related field as typically attained through a Bachelor’s Degree; and/or an equivalent combination of education and experience.

  • Thorough knowledge of small animal surgery and anatomy, mouse husbandry, and reproductive functions.

  • Demonstrated ability to handle, inject, euthanize, and collect tissues from mice.

  • Proven experience working with a variety of laboratory equipment, including but not limited to equipment used with animals equipment.

  • Experience with RNA isolation, DNA isolation, DNA digestion by restriction enzymes, ligation, plasmid transformation in bacteria, RT-PCR, PCR and gel electrophoresis.

  • Knowledge of laboratory safety including radioactive/biohazard handling and disposal techniques, and the ability to ensure laboratory compliance with required safety regulations.

  • Demonstrated experience with growing normal primary cells and cancer cells in culture using sterile technique.

  • Ability to work with tissue culture cells under sterile conditions.

  • Proficient computer skills and experience with various software packages including graphing, drawing programs, and Excel.

  • Proven experience in maintaining well-organized lab and thorough records. Basic math skills and ability to handle accounting and billing practices.

  • Good interpersonal skills to be effective in communicating and interacting with a variety of people within a large laboratory setting and in administrative components within and outside the University.

  • Strong organizational skills and the ability to organize and maintain a clean laboratory, maintain inventory, and order supplies.


  • Graduate degree or Bachelor's degree with at least 5 years of experience in research.
  • Five (5) years of experience with mice.
  • Experience with accounting practices for controlled substances.
  • Experience with management of an IACUC protocol.
  • Superior oral and written communication skills to communicate research results and carry out collaborative projects.
  • Experience or knowledge in other core approaches/areas of the lab, such as molecular biology (especially qPCR), biochemistry (especially chromatography), reproductive biology, or carbohydrate biology.


  • Employment is subject to a criminal background check.
  • Must be willing to perform experiments involving the handling, dissection, and sacrifice of laboratory mice. Willingness and ability to work with recombinant DNA, biohazardous materials, and toxic chemicals.
  • Must be willing to work in an environment where hazards are present, including biological (including infectious agents and bloodborne pathogens), chemical hazards, and in which there may be exposure to animal allergens and willingness to perform mouse research. Work occurs in an environment with scientific discussions of a sexual nature.
  • Must be willing to undergo DEA background check and perform record keeping and administration of controlled substances in animals as needed. Must also be willing and able to interact with the PI and other lab members within close proximity (less than 6 ft) to receive training in lab specific practices, protocols, and research.

UC San Diego Health is the only academic health system in the San Diego region, providing leading-edge care in patient care, biomedical research, education, and community service. Our facilities include two university hospitals, a National Cancer Institute-designated Comprehensive Cancer Center, Shiley Eye Institute, Sulpizio Cardiovascular Center, and several outpatient clinics. UC San Diego Medical Center in Hillcrest is a designated Level I Trauma Center and has the only Burn Center in the county. We invite you to join our dynamic team!


Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.


UC San Diego Health is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, age, protected veteran status, gender identity or sexual orientation. For the complete University of California nondiscrimination and affirmative action policy see: http://www-hr.ucsd.edu/saa/nondiscr.html

UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.

UC San Diego School of Medicine
Payroll Title:
Salary Range
Commensurate with Experience
Appointment Type:
Appointment Percent:
RX Contract
Total Openings:
Work Schedule:
Days, 8 hrs/day, Monday-Friday


As a federally-funded institution, UC San Diego Health maintains a marijuana and drug free campus. New employees are subject to drug screening.